2012

Vaccines

De Groot AS, Levitz L, Ardito MT, Skowron G, Mayer KH, Buus S, Boyle CM, Martin WD. Further progress on defining highly conserved immunogenic epitopes for a global HIV vaccine:  HLA-A3-restricted GAIA Vaccine epitopes. Hum Vaccin Immunother. 2012 Jul 1;8(7). PMID: 22777092. http://tinyurl.com/GAIA-HLA-A3.

Lauren Levitz, O.A. Koita, Kotou Sangare, Matthew T. Ardito, Christine M. Boyle, John Rozehnal, Karamoko Tounkara, Sounkalo M. Dao, Youssouf Koné, Zoumana Koty, Soren Buus, Leonard Moise, William D. Martin, Anne S. De Groot. Conservation of HIV-1 T cell epitopes across time and clades: Validation of HLA-A2 epitopes selected for the GAIA HIV vaccine. Vaccine. 2012 Oct 23. pii: S0264-410X(12)01488-0. doi:10.1016/j.vaccine.2012.10.042. http://www.sciencedirect.com/science/article/pii/S0264410X12014880.

Elfaki ME, Khalil EA, De Groot AS, Musa AM, Gutiérrez Núñez A, Younis BM, Salih KA, El-Hassan AM.. Immunogenicity and immune modulatory effects of in silico predicted L-donovani candidate peptide vaccines. Human Vaccines and Immunotherapy. Hum Vaccin Immunother. 2012 Aug 24;8(12).  PMID:22922767. http://www.psychepharmaceuticals.com/journals/vaccines/toc/volume/8/issue/7/.

Ruicheng Wei*, Chunfu Yang, Mei Zeng, Frances Terry, Qinsong Pan, Kai Zhu, Chunhui Yang, Chaoyang Deng Ralf Altmeyer, William Martin, Anne S. De Groot and Qibin Leng. A Dominant EV71-specific CD4+ T cell epitope is Highly Conserved Among Human Enteroviruses. Submitted 2012. Accepted PLOS One D12-29672.

De Groot AS. Fifth Vaccine Renaissance introduction. Hum Vaccin Immunother. 2012 Jul;8(7):960. doi: 10.4161/hv.21442. Epub 2012 Jul 1. No abstract available. PMID: 22832257.

Spero D, Petrovsky N, De Groot AS. Report from the field: Fifth Vaccine Renaissance in Providence RI. Hum Vaccin Immunother. 2012 Jul;8(7):1006-9. doi: 10.4161/hv.19779. Epub 2012 Jul 1.

Review. Gutiérrez AH, Spero D, Gay C, Zimic M, De Groot AS. New vaccines needed for pathogens infecting animals and humans : One Health. Hum Vaccin Immunother. 2012 Jul 1;8(7). PMID:22485046 http://www.landesbioscience.com/journals/vaccines/article/20202/?nocache=1531057775.

Review. Leonard Moise, Steven F. Moss and Anne S. De Groot. Moving H. pylori Vaccine Development Forward with Bioinformatics and Immunomics. Invited Editorial for Expert Rev Vaccines. 2012 Sep;11(9):1031-3. doi: 10.1586/erv.12.80.

Missa P. Sanou, Anne S. De Groot, Michael Murphey-Corb, Jay A. Levy, and Janet K. Yamamoto HIV-1 Vaccine Trials: Evolving Concepts and Designs. Open AIDS Journal. Accepted, to be published in November 2012.

Access to Care

Ahmed Eldakrourey, Ericka Olivera, Rebecca Martin, Anne S. De Groot. Adherence to American Diabetes Association Guidelines in a Volunteer-run Free Clinic for the Uninsured in Providence, Rhode Island: Comparison with Standards Achieved by Clinics for Insured Patients. Journal of Medicine and Health, Rhode Island. Journal of Medicine and Health RI. Accepted, In Press. 2012.

Protein Therapeutics and Tolerance (to Protein Drugs)

Proceedings. De Groot A.S., Cohen TC, Moise, L, Martin WD. Reducing Protein Immunogenicity by Design: Deimmunization and Tolerance Induction. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009 . ESACT Proceedings, 2012, Volume 5, Part 6, 525-534, DOI: 10.1007/978-94-007-0884-6_90. Published on line in 2012 at http://www.springerlink.com/content/w086t8065l666g74/?MUD=MP.

Chapter. Vibha Jawa; Leslie Cousens and Anne S. De Groot. Immunogenicity of Therapeutic Fusion proteins: Contributory Factors and Clinical Experience. Chapter in: Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges, John Wiley and Sons, Inc.

Moise L, Song C, Martin WD, Tassone R, De Groot AS, Scott DW. HLA DR epitope de-immunization of FVIII in vitro and in vivo. Clin Immunol. 2012 Mar;142(3):320-31. PMID:22222093. http://tinyurl.com/Moise-FVIII-Deimmunization.

Proceedings. Andres H. Gutierrez, Leonard Moise, Frances Terry, Kristen Dasilva, Chris Bailey-Kellogg, William Martin, Anne S. De Groot Immunoinformatic Analysis of Chinese Hamster Ovary (CHO) Protein Contaminants in Therapeutic Protein Formulations, J. Immunologic Methods, BCB ’12 Proceedings of the ACM Conference on Bioinformatics, Computational Biology and Biomedicine, (ICIW) Pages 637-642.

Cousens LP, Najafian N, Mingozzi F, Elyaman W, Mazer B, Moise L, Messitt TJ, Su Y, Sayegh M, High K, Khoury SJ, Scott DW, De Groot AS. In Vitro and In Vivo Studies of IgG-Derived Treg Epitopes (Tregitopes):  A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity. J Clin Immunol. 2012 Sep 2. PMID:22941509. http://tinyurl.com/Cousens-Tregitope-JClinImmunol.

Osipovitch DC, Parker AS, Makokha CD, Desrosiers J, Kett WC, Moise L, Bailey-Kellogg C, Griswold KE. Design and analysis of immune-evading enzymes for ADEPT therapy. Protein Eng Des Sel. 2012 Oct;25(10):613-24. Epub 2012 Aug 16. PMID: 22898588 [PubMed - in process]. http://peds.oxfordjournals.org/content/25/10/613.long.

Gutiérrez AH, Moise L, De Groot AS, Of [Hamsters] and Men: A New Perspective on Host Cell Proteins. Hum. Vaccin. Immunother. 2012 8 (9). 2012. http://www.landesbioscience.com/journals/vaccines/article/22378/ http://www.slideshare.net/AnnieDG/cho-hcp-immunogenicity-iciw-bailey-kellog.

Autoimmunity

van der Marel S, Majowicz A, Kwikkers K, van Logtenstein R, te Velde AA, De Groot AS, Meijer SL, van Deventer SJ, Petry H, Hommes DW, Ferreira V. Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis. World Journal of Gastroenterology. World J Gastroenterol. 2012 Aug 28;18(32):4288-99. http://www.wjgnet.com/1007-9327/full/v18/i32/4288.htm.

Cousens LP, Najafian N, Mingozzi F, Elyaman W, Mazer B, Moise L, Messitt TJ, Su Y, Sayegh M, High K, Khoury SJ, Scott DW, De Groot AS. In Vitro and In Vivo Studies of IgG-Derived Treg Epitopes (Tregitopes):  A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity. J Clin Immunol. 2012 Sep 2. PMID:22941509. http://tinyurl.com/Cousens-Tregitope-JClinImmunol.

Autoimmunity-Tregitope

Review. Cousens LP, Tassone R, Mazer BD, Ramachandiran V, Scott DW, De Groot AS. Tregitope Update: Mechanism of Action Parallels IVIg. Autoimmun Rev. 2012 Aug 28. PMID:22944299 http://tinyurl.com/Cousens-Tregitope-Autoimmunity.

Review. Cousens LP, Mingozzi F, van der Marel S, Su Y, Garman R, Ferreira V, Martin W, Scott DW, De Groot AS. Teaching Tolerance: New Approaches to Enzyme Replacement Therapy for Pompe Disease. Hum. Vaccin. Immunother. 2012 Oct;8 (10). On line 2012. http://tinyurl.com/De-Groot-Tregitope-Pompe.

Emerging Infectious Diseases

Morishima C, Di Bisceglie AM, Rothman AL, Bonkovsky HL, Lindsay KL, Lee WM, Koziel MJ, Fontana RJ, Kim HY, Wright EC, HALT-C Trial Group. Antigen-specific lymphocyte proliferation decreases over time in advanced chronic hepatitis C. J Viral Hepat 2012; 19:404-413. PMCID: PMC3349971

Global Health

Yoon IK, Rothman AL, Tannitisupawong D, Srikiatkhachorn A, Jarman RG, Aldstadt J, Nisalak A, Mammen MP Jr., Thammapalo S, Green S, Libraty DH, Gibbons RV, Getis A, Endy T, Jones JW, Koenraadt CJM, Morrison AC, Fansiri T, Pimgate C, Scott TW. Underrecognized mildly symptomatic viremic dengue virus infections in rural Thai schools and villages. J Infect Dis 2012; 206:389-398. PMCID: Journal to submit

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